Abraham's world. The city appears early. Abram chases the raiding kings as far as Hobah, north of Damascus (Genesis 14:15), and when he worries that he has no heir, he names his servant Eliezer of Damascus as the one who would inherit (Genesis 15:2).
Kings of Aram. David placed garrisons in Aram of Damascus (2 Samuel 8:5), but under Solomon a rebel named Rezon made the city his base (1 Kings 11:23). Later kings called Ben-Hadad fought Israel again and again. Elijah was sent toward Damascus with a word about a future king named Hazael (1 Kings 19:15), and Elisha later wept in the city itself, foreseeing the harm Hazael would do to Israel (2 Kings 8:7).
Naaman. A commander of Aram's army with a skin disease was pointed to Israel's prophet by a captured Israelite girl. Told to wash seven times in the Jordan, Naaman was offended, then persuaded by his servants, and came up healed (2 Kings 5:14). Jesus later recalled him as proof that God's mercy had always reached beyond Israel (Luke 4:27).
Fall to Assyria. In 732 BC the Assyrian king Tiglath-pileser III captured Damascus and ended the kingdom of Aram (2 Kings 16:9).
Paul on the road. Centuries later Saul of Tarsus set out for Damascus with letters to arrest followers of Jesus. Near the city a light from heaven threw him down, and the risen Jesus asked why he was persecuting him (Acts 9:3). Blind, he was led into the city to a house on the street called Straight. There a disciple named Ananias, afraid but obedient, laid hands on him and called him brother (Acts 9:17).
““Get up!” the Lord told him. “Go to the house of Judas on Straight Street and ask for a man from Tarsus named Saul, for he is praying.”
Saul began preaching that Jesus is the Son of God. When a plot against his life had the gates watched, believers lowered him through the wall in a basket (Acts 9:23). Paul later recalled that escape (2 Corinthians 11:32) and his return to Damascus after time in Arabia (Galatians 1:17).